Article
A Conserved Proline Hinge Mediates Helix Dynamics and Activation of Rhodopsin.
Structure (London, England : 1993) - 1 Sept 2020
Pope Andreyah L, Sanchez-Reyes Omar B, South Kieron, Zaitseva Ekaterina, Ziliox Martine, Vogel Reiner, Reeves Philip J, Smith Steven O
Abstract excerpt
Despite high-resolution crystal structures of both inactive and active G protein-coupled receptors (GPCRs), it is still not known how ligands trigger the large structural change on the intracellular side of the receptor since the conformational changes that occur within the extracellular ligand-binding region upon activation are subtle. Here, we use solid-state NMR and Fourier transform infrared spectroscopy on...
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