Structural characterization of a 14-residue peptide ligand of the retinoblastoma protein: comparison with a nonbinding analog.

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Article

Structural characterization of a 14-residue peptide ligand of the retinoblastoma protein: comparison with a nonbinding analog.

Peptide research - 1 Jan 2000

Breese K, Friedrich T, Andersen T T, Smith T F, Figge J

Abstract excerpt

The retinoblastoma protein, a 110-kDa nuclear anti-oncoprotein, complexes specifically with transforming proteins of several oncogenic DNA viruses. A peptide [NLFCSEEMPSSDDE] derived from one of the viral proteins (simian virus 40 large T antigen) is known to competitively bind retinoblastoma pro...

Topics

Amino Acid Sequence
Antigens, Polyomavirus Transforming
Circular Dichroism
Humans
In Vitro Techniques
Ligands
Molecular Sequence Data
Mutation
Peptide Fragments
Protein Conformation
Retinoblastoma Protein

Source

Open in PubMed

Identifiers

PMID: 1823601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1823601-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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