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Article

Structural characterization of a 14-residue peptide ligand of the retinoblastoma protein: comparison with a nonbinding analog.

Peptide research - 1 Jan 2000

Breese K, Friedrich T, Andersen T T, Smith T F, Figge J

Abstract excerpt

The retinoblastoma protein, a 110-kDa nuclear anti-oncoprotein, complexes specifically with transforming proteins of several oncogenic DNA viruses. A peptide [NLFCSEEMPSSDDE] derived from one of the viral proteins (simian virus 40 large T antigen) is known to competitively bind retinoblastoma protein, but a mutant analog [NLFCSKEMPSSDDE] does not. We studied the T peptide with HPLC to determine whether it can...

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PMID: 1823601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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