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Article

Rhodopsin activation exposes a key hydrophobic binding site for the transducin alpha-subunit C terminus.

The Journal of biological chemistry - 9 Jul 2004

Janz Jay M, Farrens David L

Abstract excerpt

Conformational changes enable the photoreceptor rhodopsin to couple with and activate the G-protein transducin. Here we demonstrate a key interaction between these proteins occurs between the C terminus of the transducin alpha-subunit (G(Talpha)) and a hydrophobic cleft in the rhodopsin cytoplasmic face exposed during receptor activation. We mapped this interaction by labeling rhodopsin mutants with the...

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Identifiers

PMID: 15070895
DOI: 10.1074/jbc.M402567200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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