Article
Minisatellite instability is found in colorectal tumours with mismatch repair deficiency.
British journal of cancer - 16 Nov 2001
Coleman M G, Gough A C, Bunyan D J, Braham D, Eccles D M, Primrose J N
Abstract excerpt
Microsatellite instability (MSI) in colorectal tumours is demonstrated by PCR amplification of several different microsatellite loci. Minisatellites, which are repeats of longer sequences also found throughout the genome, may also be affected by tumorigenesis. Certain minisatellite alleles contain 2 types of similar repeat unit that are randomly interspersed. The interspersion pattern can be analysed by mapping...
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