Article
Increasing relevance of pharmacogenetics of drug metabolism in clinical practice.
Internal medicine journal - 1 Nov 2001
Pillans P I
Abstract excerpt
Much of the individual variation in drug response is due to genetic drug metabolic polymorphisms. Clinically relevant examples include acetylator status; cytochrome P450 2D6, 2C9 and 2C19 polymorphisms; and thiopurine methyltransferase deficiency. It is important to be aware of which drugs are subject to pharmacogenetic variability. In the future, population-based pharmacogenetic testing will allow more...
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