Article
Pharmacogenomics: the inherited basis for interindividual differences in drug response.
Annual review of genomics and human genetics - 1 Jan 2001
Evans W E, Johnson J A
Abstract excerpt
It is well recognized that most medications exhibit wide interpatient variability in their efficacy and toxicity. For many medications, these interindividual differences are due in part to polymorphisms in genes encoding drug metabolizing enzymes, drug transporters, and/or drug targets (e.g., receptors, enzymes). Pharmacogenomics is a burgeoning field aimed at elucidating the genetic basis for differences in drug...
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