Article
Pharmacogenetics: the slow, the rapid, and the ultrarapid.
15 Mar 1994
Abstract excerpt
Pharmacogenetics, the study of genetically determined variations in drug response, has its origins in discoveries made in the 1950s. In 1957, Motulsky (1) pointed out that certain adverse drug reactions could be caused by genetically determined variations in enzyme activity. It was recognized that variants of glucose-6-phosphate dehydrogenase caused primaquine-induced hemolysis (2) and that pseudocholinesterase...