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Article

The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.

The Journal of biological chemistry - 15 Feb 2002

Nohe Anja, Hassel Sylke, Ehrlich Marcelo, Neubauer Florian, Sebald Walter, Henis Yoav I, Knaus Petra

Abstract excerpt

Bone morphogenetic proteins (BMPs) are multifunctional proteins regulating cell growth, differentiation, and apoptosis. BMP-2 signals via two types of receptors (BRI and BRII) that are expressed at the cell surface as homomeric as well as heteromeric complexes. Prior to ligand binding, a low but measurable level of BMP-receptors is found in preformed hetero-oligomeric complexes. The major fraction of the...

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PMID: 11714695
DOI: 10.1074/jbc.M102750200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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