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Article

BMP heterodimers signal via distinct type I receptor class functions.

Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2021

Tajer Benjamin, Dutko James A, Little Shawn C, Mullins Mary C

Abstract excerpt

Heterodimeric TGF-β ligands outperform homodimers in a variety of developmental, cell culture, and therapeutic contexts; however, the mechanisms underlying this increased potency remain uncharacterized. Here, we use dorsal-ventral axial patterning of the zebrafish embryo to interrogate the BMP2/7 heterodimer signaling mechanism. We demonstrate that differential interactions with BMP antagonists do not account for...

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Identifiers

PMID: 33827919
DOI: 10.1073/pnas.2017952118
PMCID: PMC8054026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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