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Article

Assembly of TbetaRI:TbetaRII:TGFbeta ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependent.

Journal of molecular biology - 16 Dec 2005

Zúñiga Jorge E, Groppe Jay C, Cui Yumin, Hinck Cynthia S, Contreras-Shannon Verónica, Pakhomova Olga N, Yang Junhua, Tang Yuping, Mendoza Valentín, López-Casillas Fernando, Sun LuZhe, Hinck Andrew P

Abstract excerpt

Transforming growth factor-beta (TGFbeta) isoforms initiate signaling by assembling a heterotetrameric complex of paired type I (TbetaRI) and type II (TbetaRII) receptors on the cell surface. Because two of the ligand isoforms (TGFbetas 1, 3) must first bind TbetaRII to recruit TbetaRI into the complex, and a third (TGFbeta2) requires a co-receptor, assembly is known to be sequential, cooperative and...

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Identifiers

PMID: 16289576
DOI: 10.1016/j.jmb.2005.10.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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