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Article

The C-terminal tail of the dual-specificity Cdc25B phosphatase mediates modular substrate recognition.

Biochemistry - 27 Nov 2001

Wilborn M, Free S, Ban A, Rudolph J

Abstract excerpt

Cdc25 is a dual-specificity phosphatase that catalyzes the activation of the cyclin-dependent kinases (Cdk/cyclins), thus triggering initiation and progression of successive phases of the cell cycle. In our efforts to elucidate the interaction between Cdc25B and the natural substrate, bis-phosphorylated Cdk2/CycA (Cdk2-pTpY/CycA), we have previously found that the 17 residues of the C-terminal tail mediate a...

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Identifiers

PMID: 11714273
DOI: 10.1021/bi015638h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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