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Article

Conservation and function of a potential substrate-binding domain in the yeast Clb5 B-type cyclin.

Molecular and cellular biology - 1 Jul 2000

Cross F R, Jacobson M D

Abstract excerpt

Cyclin A contains a region implicated in binding to the p27 inhibitor and to substrates. There is strong evolutionary conservation of surface residues contributing to this region in many cyclins, including yeast B-type cyclins, despite the absence of a yeast p27 homolog. The yeast S-phase B-type cyclin Clb5p interacted with mammalian p27 in a two-hybrid assay. This interaction was disrupted by mutations designed...

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Identifiers

PMID: 10848604
DOI: 10.1128/MCB.20.13.4782-4790.2000
PMCID: PMC85916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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