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Article

The energetic network of hotspot residues between Cdc25B phosphatase and its protein substrate.

Journal of molecular biology - 6 Oct 2006

Sohn Jungsan, Rudolph Johannes

Abstract excerpt

We have investigated the functional network of hotspot residues at the remote docking site of two cell cycle regulators, namely Cdc25B phosphatase and its native protein substrate Cdk2-pTpY/CycA. Specifically, we have studied the roles of energetically important residues (Arg488, Arg492, Tyr497 on Cdc25B and Asp206 and Asp210 on Cdk2-pTpY/CycA) by generating a diverse set of substitutions and performing double...

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Identifiers

PMID: 16950393
DOI: 10.1016/j.jmb.2006.07.090
PMCID: PMC1769329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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