Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the mechanism of C473D mutation on CDC25B causing weak binding affinity with CDK2/CyclinA by molecular dynamics study.

Journal of biomolecular structure & dynamics - 1 Jan 2023

Li Li-Peng, Li Hao-Xin, Zhou Hui, Li Wei-Ya, Wang Run-Ling, Zhang Ying-Chi, Ma Ying

Abstract excerpt

CDC25B belongs to the CDC25 family, and it plays an important part in regulating the activity of CDK/CyclinA. Studies have shown that CDC25B is closely related to cancer development. When CYS473 on CDC25B is mutated into ASP, the affinity between CDC25B and CDK2/CyclinA weakens, and their dissociation speed is greatly improved. However, the mechanism by which the CDC25BC473D mutant weakens its binding to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Source

Identifiers

PMID: 36655391
DOI: 10.1080/07391102.2023.2166995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the mechanism of C473D mutation on CDC25B causing weak binding affinity with CDK2/CyclinA by molecular dynamics study.PMID 36655391Read ↗

Molecular dynamics simulations reveal the activation mechanism of mutations G12V and Q61L of Cdc42.Semantic proximity Read ↗

CDC25B is associated with the risk of hepatocellular carcinoma, but not related to persistent infection of hepatitis B virus in a Chinese population.Semantic proximity Read ↗

Phosphorylation of CDC25A on SER283 in late S/G2 by CDK/cyclin complexes accelerates mitotic entry.Semantic proximity Read ↗

Highlighting the Major Role of Cyclin C on Cyclin-Dependent Kinase 8 Activity by Molecular Dynamics SimulationsSemantic proximity Read ↗

Specific Conformational Dynamics and Expansion Underpin a Multi-Step Mechanism for Specific Binding of p27 with Cdk2/Cyclin A.Semantic proximity Read ↗

Molecular dynamics simulations and statistical coupling analysis reveal functional coevolution network of oncogenic mutations in the CDKN2A-CDK6 complex.Semantic proximity Read ↗

All-Atomic Molecular Dynamic Studies of Human and Drosophila CDK8: Insights into Their Kinase Domains, the LXXLL Motifs, and Drug Binding Site.Semantic proximity Read ↗

The energetic network of hotspot residues between Cdc25B phosphatase and its protein substrate.Semantic proximity Read ↗

Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2.Semantic proximity Read ↗

A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25.Semantic proximity Read ↗

The molecular mechanism behind protein kinase B natural mutant E17K affecting the allosteric inhibitor sensitivity: a molecular dynamics simulation study.Semantic proximity Read ↗

Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.