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Article

Regulation of nuclear poly(A) addition controls the expression of immunoglobulin M secretory mRNA.

The EMBO journal - 15 Nov 2001

Phillips C, Jung S, Gunderson S I

Abstract excerpt

B-cell differentiation is accompanied by a dramatic increase in cytoplasmic accumulation and stability of the IgM heavy chain (mu) secretory mRNA. Despite considerable effort, the mechanism is unknown. We have identified three short motifs upstream of the secretory poly(A) site, which, when mutated in the mu heavy chain gene, significantly increase the accumulation of the secretory form of poly(A)(+) mRNA...

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Identifiers

PMID: 11707415
DOI: 10.1093/emboj/20.22.6443
PMCID: PMC125739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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