Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

U1A inhibits cleavage at the immunoglobulin M heavy-chain secretory poly(A) site by binding between the two downstream GU-rich regions.

Molecular and cellular biology - 1 Jul 2004

Phillips Catherine, Pachikara Niseema, Gunderson Samuel I

Abstract excerpt

The immunoglobulin M heavy-chain locus contains two poly(A) sites which are alternatively expressed during B-cell differentiation. Despite its promoter proximal location, the secretory poly(A) site is not expressed in undifferentiated cells. Crucial to the activation of the secretory poly(A) site during B-cell differentiation are changes in the binding of cleavage stimulatory factor 64K to GU-rich elements...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Composition
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin M

Share to Polyadenylation

Share to Protein Subunits

Share to Ribonucleoprotein, U1 Small Nuclear

Share to RNA Precursors

Share to RNA Processing, Post-Transcriptional

Source

Open in PubMed Open full text

Identifiers

PMID: 15226420
DOI: 10.1128/MCB.24.14.6162-6171.2004
PMCID: PMC434241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

U1A inhibits cleavage at the immunoglobulin M heavy-chain secretory poly(A) site by binding between the two downstream GU-rich regions.PMID 15226420Read ↗

Regulation of nuclear poly(A) addition controls the expression of immunoglobulin M secretory mRNA.Semantic proximity Read ↗

Sequences adjacent to the 5' splice site control U1A binding upstream of the IgM heavy chain secretory poly(A) site.Semantic proximity Read ↗

A functional human Poly(A) site requires only a potent DSE and an A-rich upstream sequence.Semantic proximity Read ↗

Macrophage differentiation is marked by increased abundance of the mRNA 3’ end processing machinery, altered poly(A) site usage, and sensitivity to the level of CstF64Semantic proximity Read ↗

hnRNP F influences binding of a 64-kilodalton subunit of cleavage stimulation factor to mRNA precursors in mouse B cells.Semantic proximity Read ↗

Upstream and downstream cis-acting elements for cleavage at the L4 polyadenylation site of adenovirus-2.Semantic proximity Read ↗

Bipartite structure of the downstream element of the mouse beta globin (major) poly(A) signal.Semantic proximity Read ↗

Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.