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Article

Sumoylation regulates multiple aspects of mammalian poly(A) polymerase function.

Genes & development - 15 Feb 2008

Vethantham Vasupradha, Rao Nishta, Manley James L

Abstract excerpt

The addition of the poly(A) tail to the ends of eukaryotic mRNAs is catalyzed by poly(A) polymerase (PAP). PAP activity is known to be highly regulated, for example, by alternative splicing and phosphorylation. In this study we show that the small ubiquitin-like modifier (SUMO) plays multiple roles in regulating PAP function. Our discovery of SUMO-conjugated PAP began with the observation of a striking pattern of...

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Identifiers

PMID: 18281463
DOI: 10.1101/gad.1628208
PMCID: PMC2238671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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