Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Poly(A) tail length control in Saccharomyces cerevisiae occurs by message-specific deadenylation.

Molecular and cellular biology - 1 Nov 1998

Brown C E, Sachs A B

Abstract excerpt

We report that newly synthesized mRNA poly(A) tails are matured to precise lengths by the Pab1p-dependent poly(A) nuclease (PAN) of Saccharomyces cerevisiae. These results provide evidence for an initial phase of mRNA deadenylation that is required for poly(A) tail length control. In RNA 3'-end processing extracts lacking PAN, transcripts are polyadenylated to lengths exceeding 200 nucleotides. By contrast, in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fungal Proteins
Share to Gene Expression Regulation, Fungal
Share to Microfilament Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to RNA, Messenger

Share to RNA Processing, Post-Transcriptional

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9774670
DOI: 10.1128/MCB.18.11.6548
PMCID: PMC109240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Poly(A) tail length control in Saccharomyces cerevisiae occurs by message-specific deadenylation.PMID 9774670Read ↗

Positive and negative regulation of poly(A) nuclease.Semantic proximity Read ↗

Species-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts.Semantic proximity Read ↗

A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript.Semantic proximity Read ↗

Molecular Insights into mRNA Polyadenylation and DeadenylationSemantic proximity Read ↗

Genetic analysis of polyadenylation patterns reveals distinct classes of yeast genes and local chromatin effects on Pol II elongation.Semantic proximity Read ↗

The PolyA tail length of yeast histone mRNAs varies during the cell cycle and is influenced by Sen1p and Rrp6p.Semantic proximity Read ↗

The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex.Semantic proximity Read ↗

Conditional defect in mRNA 3' end processing caused by a mutation in the gene for poly(A) polymerase.Semantic proximity Read ↗

Efficient translation of poly(A)-deficient mRNAs in Saccharomyces cerevisiae.Semantic proximity Read ↗

Direct and indirect consequences of <i>PAB1</i> deletion in the regulation of translation initiation, translation termination, and mRNA decaySemantic proximity Read ↗

Importance of polyadenylation in the selective elimination of meiotic mRNAs in growing S. pombe cells.Semantic proximity Read ↗

Arabidopsis thaliana poly (A) binding protein 2 (PAB2) functions in yeast translational and mRNA decay processes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.