Article
The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity.
The Journal of biological chemistry - 25 Jan 2002
Ponimaskin Evgeni G, Heine Martin, Joubert Lara, Sebben Michele, Bickmeyer Ulf, Richter Diethelm W, Dumuis Aline
Abstract excerpt
We have reported recently that the mouse 5-hydroxytryptamine(4a) (5-HT(4(a))) receptor undergoes dynamic palmitoylation (Ponimaskin, E. G., Schmidt, M. F., Heine, M., Bickmeyer, U., and Richter, D. W. (2001) Biochem. J. 353, 627-663). In the present study, conserved cysteine residues 328/329 in the carboxyl terminus of the 5-HT(4(a)) receptor were identified as potential acylation sites. In contrast to other...
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