Article
Role of the N-terminal region in G protein-coupled receptor functions: negative modulation revealed by 5-HT2B receptor polymorphisms.
Molecular pharmacology - 1 Jan 2014
Belmer Arnauld, Doly Stephane, Setola Vincent, Banas Sophie M, Moutkine Imane, Boutourlinsky Katia, Kenakin Terry, Maroteaux Luc
Abstract excerpt
The putative role of the N-terminal region of rhodopsin-like 7 transmembrane biogenic amine receptors in agonist-induced signaling has not yet been clarified despite recent advances in 7 transmembrane receptor structural biology. Given the existence of N-terminal nonsynonymous polymorphisms (R6G;E42G) within the HTR2B gene in a drug-abusing population, we assessed whether these polymorphisms affect...
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