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Article

Functional interactions between the alpha1b-adrenoceptor and Galpha11 are compromised by de-palmitoylation of the G protein but not of the receptor.

Cellular signalling - 1 Aug 2006

Novotny Jiri, Durchankova Dana, Ward Richard J, Carrillo Juan J, Svoboda Petr, Milligan Graeme

Abstract excerpt

Both the alpha1b-adrenoceptor and Galpha11 are targets for post-translational thio-acylation that is regulated by agonist occupancy of the receptor [P.A. Stevens, J. Pediani, J.J. Carrillo, G. Milligan, J. Biol. Chem. 276 (2001) 35883]. In co-expression studies mutation of the sites of thio-acylation in the G protein or treatment of cell membranes with hydroxylamine greatly reduced agonist stimulation of...

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Share to Acylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gq-G11

Share to Guanosine 5'-O-(3-Thiotriphosphate)

Share to Palmitates

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Share to Receptors, Adrenergic, alpha-1

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Source

Identifiers

PMID: 16297597
DOI: 10.1016/j.cellsig.2005.10.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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