Article
Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling.
Molecular pharmacology - 1 Sept 2007
Renner Ute, Glebov Konstantin, Lang Thorsten, Papusheva Ekaterina, Balakrishnan Saju, Keller Bernhard, Richter Diethelm W, Jahn Reinhard, Ponimaskin Evgeni
Abstract excerpt
In the present study, we have used wild-type and palmitoylation-deficient mouse 5-hydroxytryptamine(1A) receptor (5-HT1A) receptors fused to the yellow fluorescent protein- and the cyan fluorescent protein (CFP)-tagged alpha(i3) subunit of heterotrimeric G-protein to study spatiotemporal distribution of the 5-HT1A-mediated signaling in living cells. We also addressed the question on the molecular mechanisms by...
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