Agonist stimulation increases the turnover rate of beta 2AR-bound palmitate and promotes receptor depalmitoylation.

doi:10.1021/bi9611321

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Article

Agonist stimulation increases the turnover rate of beta 2AR-bound palmitate and promotes receptor depalmitoylation.

Biochemistry - 10 Dec 1996

Loisel T P, Adam L, Hebert T E, Bouvier M

Abstract excerpt

We have characterized the dynamic nature of beta 2-adrenergic receptor palmitoylation in Sf9 cells. Under basal conditions, the turnover of receptor-bound palmitate is rapid (half-life = 9.8 +/- 1.8 min) compared to the turnover rate of the receptor protein itself (half-life = 109 +/- 10 min). Th...

Topics

Adrenergic beta-2 Receptor Agonists
Amino Acid Sequence
Animals
Baculoviridae
Binding Sites
Cells, Cultured
Cyclic AMP-Dependent Protein Kinases
Electrophoresis, Polyacrylamide Gel
Humans
Isoproterenol
Kinetics
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Palmitic Acid

Protein Binding

Receptors, Adrenergic, beta-2

Recombinant Proteins

Spodoptera

Source

Open in PubMed

Identifiers

PMID: 8961959
DOI: 10.1021/bi9611321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8961959-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Agonist stimulation increases the turnover rate of beta 2AR-bound palmitate and promotes receptor depalmitoylation.PMID 8961959Read ↗

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