Article
Molecular genetics of acute promyelocytic leukemia.
Trends in genetics : TIG - 1 May 1999
Lin R J, Egan D A, Evans R M
Abstract excerpt
The remarkable success of retinoic acid in the treatment of acute promyelocytic leukemias and the subsequent discovery that mutant forms of a retinoid acid receptor (RARalpha) are invariably associated with this disease has generated considerable interest among both clinicians and basic scientists. Studies both in cell culture and in transgenic animals suggest that mutant RARs interfere with normal...
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