Article
Six microsatellite markers on the short arm of chromosome 6 in relation to HLA-DR3 and TNF-308A in systemic lupus erythematosus.
Genes and immunity - 1 Nov 2001
van der Linden M W, van der Slik A R, Zanelli E, Giphart M J, Pieterman E, Schreuder G M, Westendorp R G, Huizinga T W
Abstract excerpt
Differences in allelic distribution at loci surrounding the human HLA-DRB1 and tumor necrosis factor (TNF) genes have been observed in association with systemic lupus erythematosus (SLE). We investigated whether the association of HLA-DRB1*0301 (HLA-DR3) and TNF-308A with SLE could be attributed to polymorphic markers in the chromosomal region encompassed by HLA-DRB1 and HLA-C. Ninety-one consecutive Caucasian...
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