Article
Population pharmacokinetic analysis resulting in a tool for dose individualization of busulphan in bone marrow transplantation recipients.
Bone marrow transplantation - 1 Oct 2001
Sandström M, Karlsson M O, Ljungman P, Hassan Z, Jonsson E N, Nilsson C, Ringden O, Oberg G, Bekassy A, Hassan M
Abstract excerpt
The aims of the present study were (1) to investigate and quantify the pharmacokinetics, including inter-occasion variability and covariate relationships, of busulphan in BMT patients and (2) to develop a user-friendly initial dosing and therapeutic drug monitoring (TDM) strategy for the treatment of those patients with busulphan. The pharmacokinetics of busulphan was studied in 64 adults and 12 children who...
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