Article
The DERAA HLA-DR alleles in patients with early polyarthritis: protection against severe disease and lack of association with rheumatoid arthritis autoantibodies.
Arthritis and rheumatism - 1 Mar 2009
Carrier Nathalie, Cossette Pierre, Daniel Claude, de Brum-Fernandes Artur, Liang Patrick, Ménard Henri A, Boire Gilles
Abstract excerpt
OBJECTIVE: To define the association of alleles encoding the HLA-DR rheumatoid arthritis (RA) protective epitope (DERAA) with the presence of RA-associated antibodies at study inclusion and with severe outcome in patients with early polyarthritis (EPA). METHODS: Consecutive EPA patients (n = 210) were evaluated early (mean of 4.8 months after diagnosis) and prospectively (for 30 months). HLA class II typing was...
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