Article
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
Developmental cell - 1 Jul 2001
Ciruna B, Rossant J
Abstract excerpt
Although FGF signaling plays an integral role in the migration and patterning of mesoderm at gastrulation, the mechanism and downstream targets of FGF activity have remained elusive. Here, we demonstrate that FGFR1 orchestrates the epithelial to mesenchymal transition and morphogenesis of mesoderm at the primitive streak by controlling Snail and E-cadherin expression. Furthermore, we show that FGFR1 functions in...
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