Article
Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice.
Developmental biology - 1 Feb 2013
Tortelote Giovane G, Hernández-Hernández J Manuel, Quaresma Alexandre J C, Nickerson Jeffrey A, Imbalzano Anthony N, Rivera-Pérez Jaime A
Abstract excerpt
The formation of the anteroposterior axis in mice requires a Wnt3-dependent symmetry-breaking event that leads to the formation of the primitive streak and gastrulation. Wnt3 is expressed sequentially in two distinct areas of the mouse embryo before the appearance of the primitive streak; first in the posterior visceral endoderm and soon after in the adjacent posterior epiblast. Hence, although an axial...
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