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Article

Craniofacial skeletal defects of adult zebrafish Glypican 4 (knypek) mutants.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2009

LeClair Elizabeth E, Mui Stephanie R, Huang Angela, Topczewska Jolanta M, Topczewski Jacek

Abstract excerpt

The heparan sulfate proteoglycan Glypican 4 (Gpc4) is part of the Wnt/planar cell polarity pathway, which is required for convergence and extension during zebrafish gastrulation. To observe Glypican 4-deficient phenotypes at later stages, we rescued gpc4(-/-) (knypek) homozygotes and raised them for more than one year. Adult mutants showed diverse cranial malformations of both dermal and endochondral bones,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19777561
DOI: 10.1002/dvdy.22086
PMCID: PMC3011836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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