Article
Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes.
Nature communications - 3 Apr 2018
Williams Margot L K, Sawada Atsushi, Budine Terin, Yin Chunyue, Gontarz Paul, Solnica-Krezel Lilianna
Abstract excerpt
Anteroposterior (AP) axis extension during gastrulation requires embryonic patterning and morphogenesis to be spatiotemporally coordinated, but the underlying genetic mechanisms remain poorly understood. Here we define a role for the conserved chromatin factor Gon4l, encoded by ugly duckling (udu), in coordinating tissue patterning and axis extension during zebrafish gastrulation through direct positive and...
Topics
- Animals
- Body Patterning
- Cell Adhesion
- Cell Communication
- Chromatin
- Crosses, Genetic
- Erythroid-Specific DNA-Binding Factors
- Gene Expression Regulation, Developmental
- Membrane Glycoproteins
- Mutation
- Notochord
- Sequence Analysis, RNA
- Signal Transduction