Article
Analysis of tumor necrosis factor-alpha gene promoter polymorphisms in anorexia nervosa.
Psychiatric genetics - 1 Sept 2001
Ando T, Ishikawa T, Kawamura N, Karibe M, Oba M, Tatsuta N, Hara S, Takii M, Naruo T, Takei M, Kurokawa N, Nozoe S, Kubo C, Komaki G
Abstract excerpt
Elevated plasma tumor necrosis factor-alpha (TNFalpha) levels and enhanced spontaneous TNFalpha release from peripheral blood mononuclear cells in patients with anorexia nervosa (AN) have been reported. TNFalpha activates the hypothalamic-pituitary-adrenal axis and reduces food intake, which is characteristic of eating disorders. Recently, three novel polymorphisms in the 5'-flanking region of the TNFalpha gene...
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