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Article

Genetic polymorphisms of inflammatory response gene TNF-α and its influence on sporadic pancreatic neuroendocrine tumors predisposition risk.

Medical oncology (Northwood, London, England) - 1 Oct 2014

Karakaxas Dimitrios, Gazouli Maria, Coker Ahmet, Agalianos Christos, Papanikolaou Ioannis S, Patapis Pavlos, Liakakos Theodoros, Dervenis Christos

Abstract excerpt

The diagnosed incidence of pancreatic neuroendocrine tumors (pNETs) is increasing; however, their etiology remains poorly understood. PNETs are a rare, heterogeneous group of tumors arising from the endocrine cells of the pancreas, and genetic risk factors for sporadic pNETs are inadequately understood. It is known that pNETs secrete biogenic amines, hormones and growth factors, tumor necrosis factor-a (TNF-α)...

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PMID: 25213764
DOI: 10.1007/s12032-014-0241-z

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TNF

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