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Article

Effect of the polymorphism of tumor necrosis factor-alpha-308 G/A gene promoter on the susceptibility to ulcerative colitis: a meta-analysis.

Digestion - 1 Jan 2008

Lu Zonghai, Chen Lei, Li Hui, Zhao Yanjun, Lin Lin

Abstract excerpt

BACKGROUND: Ulcerative colitis (UC) is a complex polygenic disease in which gene-environment interactions are important. Some studies have reported that proinflammatory polymorphisms in tumor necrosis factor-alpha-308 (TNF-alpha-308) gene promoter (substitution G-->A, designated as TNF1 and TNF2) is associated with increased UC risk. However, the results of individual studies have been inconsistent. METHODS: To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18827481
DOI: 10.1159/000158605

Genes

TNF

Provenance

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