Article
Heritable differences in the effects of amphetamine but not DOI on startle gating in albino and hooded outbred rat strains.
Pharmacology, biochemistry, and behavior - 1 Apr 2003
Swerdlow Neal R, Shoemaker Jody M, Platten Amanda, Pitcher Leia, Goins Jana, Crain Sarah
Abstract excerpt
Sensorimotor gating, measured by prepulse inhibition (PPI) of the startle reflex, is reduced in schizophrenia patients and in rats treated with dopamine (DA) agonists. Strain and substrain differences in the sensitivity to the PPI-disruptive effects of DA agonists may provide insight into the basis for human population differences in sensorimotor gating. We reported heritable differences in sensitivity to the...
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