Article
Neural basis for a heritable phenotype: differences in the effects of apomorphine on startle gating and ventral pallidal GABA efflux in male Sprague-Dawley and Long-Evans rats.
Psychopharmacology - 1 Dec 2009
Qu Ying, Saint Marie Richard L, Breier Michelle R, Ko David, Stouffer David, Parsons Loren H, Swerdlow Neal R
Abstract excerpt
RATIONALE: Prepulse inhibition (PPI) of startle is a measure of sensorimotor gating that is heritable and deficient in certain psychiatric disorders, including schizophrenia. Sprague-Dawley (SD) rats are more sensitive to PPI disruptive effects of dopamine (DA) agonists at long interstimulus intervals (60-120 ms) and less sensitive to their PPI-enhancing effects at short (10-30 ms), compared with Long-Evans (LE)...
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