Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sensory and sensorimotor gating-disruptive effects of apomorphine in Sprague Dawley and Long Evans rats.

Behavioural brain research - 2 Apr 2010

Breier Michelle R, Lewis Brittanni, Shoemaker Jody M, Light Gregory A, Swerdlow Neal R

Abstract excerpt

RATIONALE: Rat strains differ in sensitivity to the disruptive effects of dopamine agonists on sensorimotor gating, measured by prepulse inhibition (PPI) of startle. For example, Sprague Dawley (SD) rats are more sensitive to PPI-disruptive effects of apomorphine (APO) compared to Long Evans (LE) rats; F1 (SDxLE) and N2 generations exhibit intermediate phenotypes. We reported that APO increased S2/S1 ratios and...

Topics

Acoustic Stimulation
Analysis of Variance
Animals
Apomorphine
Behavior, Animal
Dopamine Agonists
Dose-Response Relationship, Drug
Electroencephalography
Evoked Potentials, Auditory
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Rats

Rats, Long-Evans

Rats, Sprague-Dawley

Reaction Time

Reflex, Startle

Sensory Gating

Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 20080128
DOI: 10.1016/j.bbr.2009.12.037
PMCID: PMC2834557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sensory and sensorimotor gating-disruptive effects of apomorphine in Sprague Dawley and Long Evans rats.PMID 20080128Read ↗

Strain differences in the gating-disruptive effects of apomorphine: relationship to gene expression in nucleus accumbens signaling pathways.Semantic proximity Read ↗

A novel rat strain with enhanced sensitivity to the effects of dopamine agonists on startle gating.Semantic proximity Read ↗

Neural basis for a heritable phenotype: differences in the effects of apomorphine on startle gating and ventral pallidal GABA efflux in male Sprague-Dawley and Long-Evans rats.Semantic proximity Read ↗

Toward understanding the biology of a complex phenotype: rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists.Semantic proximity Read ↗

Heritable differences in the effects of amphetamine but not DOI on startle gating in albino and hooded outbred rat strains.Semantic proximity Read ↗

Sensitivity to the dopaminergic regulation of prepulse inhibition in rats: evidence for genetic, but not environmental determinants.Semantic proximity Read ↗

Heritable differences in the dopaminergic regulation of behavior in rats: relationship to D2-like receptor G-protein function.Semantic proximity Read ↗

Auditory information processing in rat genotypes with different dopaminergic properties.Semantic proximity Read ↗

Fronto-temporal-mesolimbic gene expression and heritable differences in amphetamine-disrupted sensorimotor gating in rats.Semantic proximity Read ↗

The effects of apomorphine and D-amphetamine on striatal c-Fos expression in Sprague-Dawley and Long Evans rats and their F1 progeny.Semantic proximity Read ↗

Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats.Semantic proximity Read ↗

Prepulse startle deficit in the Brown Norway rat: a potential genetic model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.