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Article

Physiological analysis of the role of truB in Escherichia coli: a role for tRNA modification in extreme temperature resistance.

Microbiology (Reading, England) - 1 Nov 2002

Kinghorn Seonag M, O'Byrne Conor P, Booth Ian R, Stansfield Ian

Abstract excerpt

The truB gene of Escherichia coli encodes the pseudouridine-55 (psi55) synthase and is responsible for modifying all tRNA molecules in the cell at the U55 position. A truB null mutant grew normally on all growth media tested, but exhibited a competitive disadvantage in extended co-culture with its wild-type progenitor. The mutant phenotype could be complemented by both the cloned truB gene and by a D48C,...

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PMID: 12427942
DOI: 10.1099/00221287-148-11-3511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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