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Article

Suppression of chromosome segregation defects of Escherichia coli muk mutants by mutations in topoisomerase I.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2000

Sawitzke J A, Austin S

Abstract excerpt

Escherichia coli muk mutants are temperature-sensitive and produce anucleate cells. A spontaneously occurring mutation was found in a DeltamukBkan mutant strain that suppressed the temperature-sensitive phenotype and mapped in or near topA, the gene that encodes topoisomerase I. Previously characterized topA mutations, topA10 and topA66, were found to be general suppressors of muk mutants: they suppressed...

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Identifiers

PMID: 10660686
DOI: 10.1073/pnas.030528397
PMCID: PMC26494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppression of chromosome segregation defects of Escherichia coli muk mutants by mutations in topoisomerase I.PMID 10660686Read ↗

MukB colocalizes with the oriC region and is required for organization of the two Escherichia coli chromosome arms into separate cell halves.Semantic proximity Read ↗

Cloning, sequencing, and characterization of multicopy suppressors of a mukB mutation in Escherichia coli.Semantic proximity Read ↗

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The bacterial condensin MukB compacts DNA by sequestering supercoils and stabilizing topologically isolated loops.Semantic proximity Read ↗

Bacterial type 1A topoisomerases maintain the stability of the genome by preventing and dealing with R-loop-and nucleotide excision repair-dependent topological stressSemantic proximity Read ↗

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Mutants suppressing novobiocin hypersensitivity of a mukB null mutation.Semantic proximity Read ↗

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Null mutation of the dam or seqA gene suppresses temperature-sensitive lethality but not hypersensitivity to novobiocin of muk null mutants.Semantic proximity Read ↗

Mutual suppression of mukB and seqA phenotypes might arise from their opposing influences on the Escherichia coli nucleoid structure.Semantic proximity Read ↗

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