Article
Cyclin D1 (CCND1) genotype is associated with tumour grade in sporadic pituitary adenomas.
Carcinogenesis - 1 Nov 2001
Simpson D J, Fryer A A, Grossman A B, Wass J A, Pfeifer M, Kros J M, Clayton R N, Farrell W E
Abstract excerpt
The cyclin D1 (CCND1) gene contains a frequent A/G polymorphism within the splice donor region of exon 4/intron 4. CCND1 genotype is associated with clinical outcome in a number of malignancies although prognostic significance varies with tumour type. We examined CCND1 allele frequencies and genotype distribution in 294 patients with sporadic pituitary adenomas of various histologies. CCND1 allele frequencies and...
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