Article
Altered cyclin D1 genotype distribution in human sporadic pituitary adenomas.
Medical science monitor : international medical journal of experimental and clinical research - 1 Oct 2007
Gazioglu Nurperi M, Erensoy Nevin, Kadioglu Pinar, Sayitoglu Muge Aydin, Ersoy Ismail Hakki, Hatirnaz Ozden, Kisacik Bunyamin, Oz Buge, Sar Mehmet, Ozbek Ugur, Ciplak Nejat, Cagatay Penbe
Abstract excerpt
BACKGROUND: The cyclin D1 gene (CCND1) is a proto-oncogene playing a critical role in the transition through the G1 to the S phase of the cell cycle and is overexpressed in many tumors. G870A polymorphism at the exon4/intron4 splicing region of the CCND1 gene may play a role in pituitary tumorigenesis and invasiveness. The objective of this study was to examine CCND1 polymorphism in patients with different types...
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