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Article

Aberrant expression of G(1)/S regulators is a frequent event in sporadic pituitary adenomas.

Carcinogenesis - 1 Aug 2001

Simpson D J, Frost S J, Bicknell J E, Broome J C, McNicol A M, Clayton R N, Farrell W E

Abstract excerpt

Components of the pRb/p16/cyclin D1/CDK4 pathway are frequent targets in numerous tumour types, including those of pituitary origin. However, previous studies of pituitary tumours have examined individual components of this pathway. Therefore, to determine their overall contribution we have simultaneously examined the immunohistochemical status of pRb, p16 and cyclin D1 and analysed the CDK4 gene for a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11470742
DOI: 10.1093/carcin/22.8.1149

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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