Article
Association of cyclin D1 genotype with breast cancer risk and survival.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2005
Shu Xiao Ou, Moore Derek B, Cai Qiuyin, Cheng Jiarong, Wen Wanqing, Pierce Larry, Cai Hui, Gao Yu-Tang, Zheng Wei
Abstract excerpt
Cyclin D1 (CCND1) is a key cell cycle regulatory protein that governs cell cycle progression from the G(1) to S phase. A common polymorphism (A870G) in exon 4 of the CCND1 gene produces an alternate transcript (transcript-b) that preferentially encodes a protein with enhanced cell transformation activity and possible prolonged half-life. We evaluated the association of CCND1 A870G polymorphism with breast cancer...
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