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Article

Association of the cyclin D1 A870G polymorphism with advanced colorectal cancer.

JAMA - 3 Dec 2003

Le Marchand Loïc, Seifried Ann, Lum-Jones Annette, Donlon Timothy, Wilkens Lynne R

Abstract excerpt

CONTEXT: Cyclin D1 (CCND1) is a key cell cycle regulatory protein, the overexpression of which is often found in human tumors and is associated with cell proliferation and poor prognosis. A common adenine-to-guanine substitution polymorphism (A870G) in the CCND1 gene results in an altered messenger RNA transcript and a longer-life protein, which are preferentially encoded by the A allele. OBJECTIVE: To test the...

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Identifiers

PMID: 14657069
DOI: 10.1001/jama.290.21.2843

Genes

CCND1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of the cyclin D1 A870G polymorphism with advanced colorectal cancer.PMID 14657069Read ↗

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Cyclin D1 Pro241Pro (CCND1-G870A) polymorphism is associated with increased cancer risk in human populations: a meta-analysis.Semantic proximity Read ↗

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