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Article

Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.

The EMBO journal - 1 Jan 1990

Dwarki V J, Montminy M, Verma I M

Abstract excerpt

Second messengers like cAMP can activate the transcription of genes containing consesus cAMP response element (CRE). A 43 kd nuclear phosphoprotein previously identified as the cAMP response element binding (CREB) protein has been shown to bind as a dimer to CRE and activate gene transcription. The rat and human CREB protein contain the 'leucine zipper' motif. We have analyzed the role of both leucine zipper...

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Identifiers

PMID: 2136830
DOI: 10.1002/j.1460-2075.1990.tb08099.x
PMCID: PMC551651

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