Article
Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.
The EMBO journal - 1 Jan 1990
Dwarki V J, Montminy M, Verma I M
Abstract excerpt
Second messengers like cAMP can activate the transcription of genes containing consesus cAMP response element (CRE). A 43 kd nuclear phosphoprotein previously identified as the cAMP response element binding (CREB) protein has been shown to bind as a dimer to CRE and activate gene transcription. The rat and human CREB protein contain the 'leucine zipper' motif. We have analyzed the role of both leucine zipper...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cloning, Molecular
- Cyclic AMP Response Element-Binding Protein
- DNA
- DNA-Binding Proteins
- Leucine
- Macromolecular Substances
- Molecular Sequence Data
- Mutation