Article
High-resolution quantitative trait locus mapping for body weight in mice by recombinant progeny testing.
Genetical research - 1 Apr 2001
Liu X, Oliver F, Brown S D, Denny P, Keightley P D
Abstract excerpt
A major obstacle to the positional cloning of quantitative trait loci (QTLs) lies in resolving genetic factors whose allelic effects are blurred by environmental and background genetic variation. We investigate a fine-mapping approach that combines the use of an interval-specific congenic strain with progeny testing of recombinants for markers flanking a QTL. We apply the approach to map a murine QTL with an...
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