Article
Guanosine supplementation reduces apoptosis and protects renal function in the setting of ischemic injury.
The Journal of clinical investigation - 1 Nov 2001
Kelly K J, Plotkin Z, Dagher P C
Abstract excerpt
Ischemic injury to the kidney is characterized in part by nucleotide depletion and tubular cell death in the form of necrosis or apoptosis. Recently, we linked anoxia-induced apoptosis in renal cell cultures specifically to the depletion of GTP. We therefore hypothesized that enhancing GTP repletion in vivo might protect function by reducing apoptosis in postischemic tubules. Male C57 black mice (the "I" group of...
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