Article
Glibenclamide effects on renal function and histology after acute hemorrhage in rats under sevoflurane anesthesia.
Renal failure - 1 Jan 2007
Diego Luis Antonio Dos Santos, Marques Christiane D'Oliveira, Vianna Pedro Thadeu Galvão, Viero Rosa Marlene, Braz José Reinaldo Cerqueira, Castiglia Yara Marcondes Machado
Abstract excerpt
INTRODUCTION: Hypovolemia from hemorrhage evokes protective compensatory reactions, such as the renin-angiotensin system, which interferes in the clearance function and can lead to ischemia. This study was designed to evaluate the effects of glibenclamide, a K(+)(ATP) channel blocker, on renal function and histology in rats in a state of hemorrhagic shock under sevoflurane anesthesia. MATERIAL AND METHODS: Twenty...
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