Article
Association of SULT1A1 phenotype and genotype with prostate cancer risk in African-Americans and Caucasians.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2004
Nowell Susan, Ratnasinghe D Luke, Ambrosone Christine B, Williams Suzanne, Teague-Ross Terri, Trimble Lyndsey, Runnels Gail, Carrol Alindria, Green Bridgett, Stone Angie, Johnson Don, Greene Graham, Kadlubar Fred F, Lang Nicholas P
Abstract excerpt
Exposure to heterocyclic amines may increase prostate cancer risk. Human sulfotransferase 1A1 (SULT1A1) is involved in the bioactivation of some dietary procarcinogens, including the N-hydroxy metabolite of the food-borne heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo(4,5-b) pyridine. This study compares a polymorphism in the SULT1A1 gene, SULT1A1 enzyme activity, meat consumption, and the risk of prostate...
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