Article
Sulfotransferase 1A1 (SULT1A1) polymorphism and breast cancer risk in Chinese women.
Toxicology letters - 21 Apr 2004
Han Ding-Fen, Zhou Xin, Hu Ming-Bai, Wang Chun-Hong, Xie Wei, Tan Xiao-Dong, Zheng Fang, Liu Fang
Abstract excerpt
BACKGROUND: Sulfonation catalyzed by sulfotransferase enzymes plays an important role in chemical defense mechanisms against various xenobiotics but also bioactivates carcinogens. A major human sulfotransferase, SULT1A1, catalyzes the sulfation of a variety of phenolic and estrogenic compounds. A functional polymorphism of the SULT1A1 gene has been implicated in a decreased activity and thermostability when the...
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